Use libraries like PyPDF2 or pdfminer for text extraction, and reportlab for PDF creation and editing.
Tag text elements (headings, paragraphs) using semantic tags for screen readers.
Ensure that images have descriptive alt text to make them accessible for visually impaired users.
Choose fonts that are easy to read and supported by screen readers, like Arial or Times New Roman.
Organize content logically with headings, lists, and tables for clear navigation.
Use tools like axe or WAVE to test PDFs for accessibility before final deployment.